合成1 5 苯并硫氮杂卓及其衍生物的相关反应的研究word格式论文.docxVIP

优秀毕业论文 精品参考文献资料 优化工作。此项工作，为合成新型 1,5- 苯并硫氮杂卓衍生物的研究 工作提供了实验依据。 关键词：1,5-苯并硫氮杂卓 抑菌活性 亚胺型 1,5- 苯并硫氮杂卓 烯胺 型 1,5- 苯并硫氮杂卓 Abstract 1,5-benzothiazepine is a kind of compound which has important physiological activities. Some of its derivatives have been used in clinic as antianxiety drugs, hyprosis and cardiovascular medicines.Therefore, its syntheses, structures and pharmacological activities have been attracted wide attentions. Experiments proved that 1,5 – benzothiazepine are a class of compounds with specific structures. Through the antibacterial activity of the compounds,We have found that different structures of these compounds have different physiological activity. At present, the research group for the Synthesis of research work mainly focused on the synthesis of 1,5 - benzothiazepine-β-lactam and 1,5 - benzothiazepine these two types of compounds. We have analyzed antibacterial activity of all the various compounds that have been synthesized.It is the consequent that with ester of 1,5- benzo-N-imine-type heteropoly compounds Zhuo has good antibacterial activity. Our preliminary view is that ester and imine double bond are the efficacy of such compounds, functional groups. In order to clarify imine double bond is the efficacy of such compounds that is one functional group. In this paper Selective reduction methods of containing ester and double bond in the imine of 1,5 - benzo-N-imine-type heteropoly compounds Zhuo were studied. Its antimicrobial activity of1,5 - benzothiazepine derivatives will be very good if its mother ring 2 C atoms are replaced by ester. Therefore, in this thesis long chain α, β-unsaturated ketones synthetic methods are carried out relevant research. The job provides an important theoretical basis for studing of synthesis with a special pharmacological activity of 1,5 - benzothiazepine class of drugs. The main jobs in this thesis is as follows: Fristly, In this paper Selective reduction methods of containing ester and double bond in the imine