cyp2c192基因变异对pci术后抗血小板治疗效果的影响及其对策分析word格式论文.docxVIP

1.The frequency of different genotypes of CYP2C19 681 was in agreement with Hardy-Weinberg equilibriumin our study(P0.05),CYP2C19*2 GA carriers 130（42.76%）and AAcarriers34（11.18%）.By analysis of 259patients who accepted the standard antithrombotic therapy :although the recurruence of cardiac events were affected by carryingCYP2C19*2（OR:4.874，95%CI：2.397-12.392）,age（OR2.635,95%CI：1.161-5.979）,left ventricular function（OR：3.718,95%CI：1.677-13.497）、diabetes（OR：3.221，95%CI:1.875-9.504）and renal function（OR:2.429,95%CI：1.814-9.247), CYP2C19*2 variation not onlyaffcet recurrent cardiovascular events,but also positively with the residual aggregation before and after theantiplatelet thyrapy（r=0477，P＜0.001）.The CYP2C19*2 carriers has higherAgglate than patients who are notCYP2C19*2carriersaftertreatmen（tP＜0.01＝.Comparedwiththethestandardantithrombotictherapy,theAggmaxand Agglatesignificantlylower,whileIPA%(IPA%maxandIPA%late)and Disaggregationsignificantlyincrasedafter7daysinNaoXinTonginadditionwith the standard antithrombotic therapy（all P＜0.05＝.After one yearfollow-up,TherecurrenceofadversecardiovasculareventsintheNaoXinTong group are significantly lower than the standard group(P0.05).Conclusion:CYP2C19*2variationweakentheeffectofantiplateletthrapyafter PCI,andleadtohigherrecurrenceofadversecardiovasculareventsinoneyear afterPCI;NaoXinTonginadditionwiththe standard antithrombotic therapy could improvetheeffectofthetreatmentofantiplateletinthesepatientsandlowerthe recurrence of adverse cardiovascular eventsin one year after PCI .Key words:CYP2C19;Polymorphism;NaoXinTong; platelet function；adverse cardiovascular events缩略词表英文缩写英文全称中文全称ACSAcutecoronarysyndrome急性冠脉综合征ASAtherosclerosis动脉粥样硬化AMIAcutemyocardiali nfarction急性心肌STStent thrombosis支架血栓RSRestenosis再狭窄梗死CRClopidogrel resistance氯吡格雷抵抗CYP2C19CytochromeP450,family2,subfamilyC,细胞色素P450 酶,家族polypetide192,亚家族C,多肽19PCRPolymerasechainreaction多聚酶链反应RFLPRestrictionFragment LengthPolymorphism限制性片段长度多态性EDTAEthylenediaminetetraaceti