cox2在胃溃疡 胃癌的表达及其与hp感染关系的分析word格式论文.docxVIP

COX-2 in gastriculcer、gastriccancerand HPinfectionoftheexpressionandresearchoftherelationshipAbstract:Objective:ExploreCOX-2intheHPinfectionandnoninfectiousgastriculcerandgastriccancerexpression.Methods:Immunohistochemicalmethoddetectionwith196casesbygastroscopeandhistopathologicalexaminationwithgastriculcer(pathologyclassification:intestinalmetaplasia,hyperplasia),stomachandnormalgastricmucousmembraneoftheroughlythegastricmucosaCOX-2proteinexpression,ComparisonbetweenthepathologyclassificationandHPinfectionwiththeinfectionsCOX-2betweenproteinexpressionofthedifferences.Results:Thisstudyfoundthatintestinalmetaplasia,hyperplasia,stomachgroupofinflammatorycells,glandularepitheliumcells,cancercellsandnormalmucosainverysmallamountsofepithelialcellshaveCOX-2expression.Fromintestinalmetaplasia-hyperplasiaCOX-2-cancerofthestomachofpositiveexpressiontohavethetrendofincreased(P0.05).StomachcancergroupCOX-2positiveexpresshigherthangastriculcergroup(P0.05),HppositivestomachcancergroupCOX-2positiveexpresshigherthanHppositivegastriculcergroup(P0.05),HpnegativestomachcancergroupCOX-2positiveexpressionandalsohigherthanthatofHpnegativegastriculcergroup(P0.05).TheHppositivetheCOX-2positiveexpresssignificantlyhigherthanHpnegative(P0.05),theHppositivetheCOX-2positiveexpressiontohavethedifference(P0.05),HppositivestomachcancergroupCOX-2positiveexpresshigherthanHppositivegastriculcergroup(P0.05),and Hp positiveulcer COX-2 of the group expressed negative thanpositiveHp(P0.05).Conclusion:①COX-2usuallyinnormaltissuedontexpress,onlyinbyallkindsofsubstancessuchasinflammation,cellfactor,promotecanceragentunderthestimulusininflammationsiteexpression.②Fromintestinalmetaplasia-hyperplasiaCOX-2-cancerofthestomachofpositiveexpressiontohavethegrowingtrend,COX-2moreexpressedparticipatedinthestomachprecancerouslesionandtheoccurrenceofgastriccancerdevelopmentprocess.③HpinfectioncaninduceCOX-2moreexpressed.④theCOX-2intheHpinfectioninthegastricmucosaexcessiveexpression,inflammationandspeedupworsefromsupe