apoeε4等位基因对mci患者的认知功能及1hmrs代谢物的影响word格式论文.docxVIP

目录英文缩略语…………………………………………………………………………3 中文摘要……………………………………………………………………………4 英文摘要……………………………………………………………………………5 前言…………………………………………………………………………………6 材料和方法…………………………………………………………………………8 结果………………………………………………………………………………...11 讨论………………………………………………………………………………...15 结论………………………………………………………………………………...19 参考文献…………………………………………………………………………...19 致谢………………………………………………………………………………...21 综述………………………………………………………………………………...222英文缩略语（Abbreviationsandacronyms）MCI(Mildcognitive impairment)MCI-SSVD(mild cognitive impairment dueto subcorticalsmallvesseldisease) MCI—AD(mild cognitive impairment causedbyAlzheimer’s disease) MMSE(mini mentalstateexamination)MoCA(Montrealcognitive assessment) AD(Alzheimer disease) ApoE(apolipoproteinE) PCR(Polymerase chainreaction)RFLP(Restrictionfragment lengthpolymorphism) MRS(Magnetic ResonanceSpectroscopy)Sd-aMCI(single domain-amnestic MCI) md-aMCI(multiple domain-amnestic MCI)sd-naMCI(single domain-nonamnestic MCI) md-naMCl(multiple domain-nonamnestic MCI) NAA(N-acetylaspartate)Cr(creatine) Cho(choline) MI(myo-inositol)3ApoEε4等位基因对MCI患者的认知功能及1H-MRS代谢物的影响中文摘要【目的】载脂蛋白E(apolipoproteinE,ApoE)ε4等位基因是阿尔茨海默病(Alzheimerdisease,AD)的风险因素?我们目的在于研究ε4等位基因对轻度认知功能障碍(mildcognitiveimpairment,MCI)患者的认知功能及海马区磁共振波谱(Magnetic ResonanceSpectroscopy,MRS)代谢物变化的影响?【方法】对23例符合轻度认知功能障碍标准的患者进行简易精神状态检查法(minimentalstate examination,MMSE)?蒙特利尔认知评估(Montrealcognitive assessment,MoCA)检查,通过PCR-RELP技术进行ApoE基因型鉴定,并进行双侧海马区域的MRS检查?【结果】(1)ApoEε4阳性的MCI患者MoCA总分及延迟记忆分数较阴性的MCI患者降低;(2)ApoEε4阳性的MCI患者两侧海马N-乙酰天门冬氨酸/肌酸(N.acetylaspartate/creatine,NAA/Cr)显著低于ε4阴性的MCI患者,而ε4阳性的MCI 患者双侧海马胆碱/肌酸(choline/creatine,Cho/Cr) 以及肌醇/肌酸(myo- inositol/creatine,MI/Cr)无明显不同;(3)MCI患者两侧海马NAA/Cr比率与延迟回忆的分数正相关?【结论】ApoEε4等位基因阳性MCI患者记忆损害更严重,并且海马区MRS代谢物的变化能够被MRS检测到?关键词：轻度认知功能障碍,蒙特利尔认知评估,磁共振波谱,载脂蛋白E4TheimpactofApoEε4alleleoncognitiveprofilesand characteristicIHMRSprofilesofMCIABSTRACTObjectiveThepresenceoftheapolipoproteinE(ApoE)epsilon4alleleisa definiteriskfactorfortheofAlzheimersdisease(AD).Inthestudy,we aimto investigatetheimpactof ApoE