apic在大鼠体内两种不同吸收途径及其肠溶固体分散体的分析word格式论文.docxVIP

华中科技大学硕士学位论文 华 中 科 技 大 学 硕 士 学 位 论 文 优秀毕业论文 PAGE PAGE 2 精品参考文献资料 ABSTRACT This paper summarizes the pharmacokinetics of the crude drug of Angelica sinensis polysaccharide-iron complex (APIC) on account of the two different routes of absroption, preparation of the enteric-coated APIC solid dispersion based on the above to investigate the properties in vivo and in vitro of it and the study on dosage form and structure of the granules in Niferex capsule to provide academic and experimental base for enteric-coated APIC formulation. The main contents of the paper were consisted of three parts: the study of two different routes of absorbing APIC in rats; study on the enteric-coated APIC solid dispersion; the study on dosage form and structure of the granules in Niferex capsule. PartⅠ the study of two different routes of absorbing APIC in rats From the study on the property in vivo and in vitro of APIC we know that ferric ion can be released from APIC in artificial gastric juice, but no ferric ion can be released in distilled water or in artificial intestinal juice which means that APIC mainly exists as polysaccharide-iron molecular pattern. So we investigate the two different pathway of APIC absorbed in the form of ferri ion or directly in the form of polysaccharide-iron molecule in normal rats with different administration. Normal rats were assigned into three groups, APIC low, medium, and high dosage groups, ig administration with no ascorbic acid added, ig administration with ascorbic acid added and id administration were performed to investigate the pharmacokinetics of APIC absorbed in the form of ferric ion, in the form of ferric ion and polysaccharide-iron molecule and only in the form of polysaccharide-iron molecule correspondingly. Serum iron concentration was assayed by atomic absorption spectrometry after ig administration and id administration of APIC respectively. The pharmacokinetics parameters were analyzed by DAS2.0 program. The concentration-time curves