contrasting effects of vocabulary knowledge on temporal and：词汇知识在时间和时间上的对比效应精品.pdfVIP

Contrasting effects of vocabulary knowledge on temporal and parietal brain structure across lifespan 1,2 1 1 Fiona M. Richardson , Michael S. C. Thomas , Roberto Filippi , 1 2 Helen Harth Cathy J. Price 1. Developmental Neurocognition Lab, School of Psychology, Birkbeck College, University of London. 2. Wellcome Trust Centre for Neuroimaging, University College London. Word count (main text): 7223 words Address for correspondence: Dr. Fiona Richardson Wellcome Trust Centre for Neuroimaging, UCL 12 Queen Square London WC1N 3BG Email: fiona.richardson@ucl.ac.uk Tel.: +44 (0)20 7833 7488 Fax: +44 (0)20 7813 1420 Acknowledgements This research was funded by the Wellcome Trust. Fiona Richardson was supported by an MRC Career Establishment Grant G0300188 and British Academy Grant SG- 40400 awarded to Dr Michael Thomas. Our thanks to Janice Glensman, Amanda Brennan and David Bradbury for their assistance during scanning and neuropsychological testing. Abstract Using behavioral, structural and functional imaging techniques, we demonstrate contrasting effects of vocabulary knowledge on temporal and parietal brain structure in 47 healthy volunteers who ranged in age from 7 to 73. In the left posterior supramarginal gyrus, vocabulary knowledge was positively correlated with gray matter density in teenagers but not adults. This region was not activated during auditory or visual sentence processing and activation was unrelated to vocabulary skills. Its gray matter density may reflect the use of an exp