慢性稳定性心绞痛的治疗（英文）演示幻灯片.pptVIP

ACC/AHA Guidelines for Revascularization with PCI and CABG in Patients with Stable Angina (class I) ?5. PCI or CABG for patients with single- or double-vessel CAD without significant proximal LAD CAD but with a large area of viable myocardium and high-risk criteria on noninvasive testing B? 6. CABG for patients with single- or double-vessel CAD without significant proximal LAD CAD who have survived sudden cardiac death or sustained ventricular tachycardia C ?7. In patients with prior PCI, CABG or PCI for recurrent stenosis associated with a large area of viable myocardium or high-risk criteria on noninvasive testing C ?8. PCI or CABG for patients who have not been successfully treated by medical therapy and can undergo revascularization with acceptable risk B QUESTIONS?? Platelets can be activated by many platelet agonists, such as thrombin, adenosine diphosphate, collagen, serotonin, epinephrine, CD40 ligand, and as many as 70 other mediators. Each of these agonists activates a separate signal transduction pathway within platelets. All of these pathways ultimately converge on the platelet receptor GP IIb-IIIa, converting it from an inactive into an active form. The platelet receptor GP IIb-IIIa is the final common pathway to platelet aggregation, which involves binding of a single molecule of fibrinogen to two GP IIb-IIIa molecules on the surface of adjacent platelets. _________________________________________________ 1. Phillips DR, Scarborough RM. Am J Cardiol 1997;80(4A):11B-20B. Effects of nitrates in generating NO? and stimulating guanylate cyclase to cause vasodilation Printed from: Drugs for the Heart ? 2007 Elsevier Current proposals for therapy of nitrate tolerance. Printed from: Drugs for the Heart ? 2007 Elsevier A serious nitrate drug interaction Printed from: Drugs for the Heart ? 2007 Elsevier Nitrates in Angina Effect of simvastatin on cardiovascular events among patients with and without coronary heart disease (CHD) in the Heart Protec