不同剂量羟考酮对男性患者全麻苏醒期导尿管留置反应的治疗作用.docVIP

不同剂量羟考酮对男性患者全麻苏醒期导尿管留置反应的治疗作用 　　[摘要] 目的 ?^察不同剂量羟考酮对男性患者全麻苏醒期导尿管留置反应的治疗作用。 方法 选择2016年6～11月于中国医科大学附属第一医院行择期非泌尿系统手术苏醒期出现导尿管留置不适的男性患者120例，年龄20～60岁，美国麻醉医师协会（ASA）分级Ⅰ～Ⅱ级，采用随机数字表法分为A、B、C、D组，每组各30例。A、B、C组患者分别静脉注射羟考酮0.03、0.05、0.07 mg/kg，所有药物统一稀释至5 mL，D组患者静脉注射5 mL生理盐水。观察四组患者用药前后视觉模拟评分法（VAS）评分、睡眠障碍镇静评分（Ramsay评分）、生命体征变化、导尿管留置反应及不良反应。 结果 用药后A、B、C组的VAS评分、平均动脉压（MAP）、心率（HR）均低于D组（P 0.05），均优于D组（P 0.05）。 结论 静脉注射小剂量（0.03 mg/kg）羟考酮能够治疗男性患者全麻苏醒期尿管留置不适，减轻术后疼痛，有利于血流动力学稳定，而且不增加过度镇静及恶心呕吐的发生。 　　[关键词] 羟考酮；男性；全麻；导尿管留置反应 　　[中图分类号] R614.2 [文献标识码] A [文章编号] 1673-7210（2017）03（a）-0057-04 　　Therapeutical effect of different doses of Oxycodone on urethral catheter-related reaction during anesthesia recovery period after general anaesthesia in male adult patients 　　CHEN Fengshou LI Xiaoqian MA Hong 　　Department of Anesthesiology， the First Hospital of China Medical University， Liaoning Province， Shenyang 110001， China 　　[Abstract] Objective To observe curative effects of different doses of Oxycodone on urethral catheter-related reaction during anesthesia recovery period after general anaesthesia in male adult patients. Methods 120 male patients underwent elective surgery except urinary system and had urethral catheter-related reaction during anesthesia recovery period from June to November 2016 in the First Hospital Affiliated to China Medical University were enrolled， aged from 20 to 60， the American society of anesthesiologists （ASA） was Ⅰ-Ⅱ grade. All the patients were divided into four groups： group A， group B， group C， group D， according to the random number table， with 30 cases in each group. Patients of group A， group B， group C were allocated to receive Oxycodone 0.03， 0.05， 0.07 mg/kg respectively， all drugs were diluted to 5 mL with saline. Patients of group D were allocated to receive saline 5 mL. Visual analogue scale （VAS） score， Ramsay score， vital signs change， urethral catheter-related reaction before and after treatment， and adverse reactions were recorded. Results After treatm