不同剂量米非司酮对围绝经期子宫肌瘤患者肌瘤体积的影响.docVIP

不同剂量米非司酮对围绝经期子宫肌瘤患者肌瘤体积的影响 　　[摘要]目的 探?不同剂量米非司酮对围绝经期子宫肌瘤患者肌瘤体积的影响。方法 选择2015年2月～2016年2月我院收治的60例围绝经期子宫肌瘤患者作为研究对象，随机分为观察组和对照组，每组30例。对照组给予米非司酮口服，25 mg/次，1次/d；观察组给予米非司酮口服，12.5 mg/次，1次/d。比较两组的临床疗效、肌瘤体积变化情况、雌二醇（E2）和孕酮（P）水平、不良反应发生率。结果 观察组的总有效率（96.67%）与对照组（90.00%）比较，差异无统计学意义（P0.05）。与治疗前相比，两组治疗后的子宫及子宫肌瘤体积均显著缩小，差异有统计学意义（P0.05）。观察组的恶心、呕吐、多汗等不良反应总发生率（13.33%）显著低于对照组（30.00%），差异有统计学意义（P0.05）。结论 与常规剂量相比，小剂量米非司酮治疗围绝经期子宫肌瘤的效果较为理想，但小剂量治疗不良反应发生率较低，安全性更高，值得临床推广应用。 　　[关键词]不同剂量；米非司酮；子宫肌瘤；肌瘤体积 　　[中图分类号] R711.74 [文献标识码] A [文章编号] 1674-4721（2017）03（b）-0113-03 　　[Abstract]Objective To explore the influence of different doses of Mifepristone on the fibroid sizes in perimenopausal patients with uterine fibroids.Methods A total of 60 perimenopausal patients with uterine fibroids treated in our hospital from February 2015 to February 2016 were selected.They were evenly divided into the observation group and the control group in random，30 cases in each group.In the control group，25 mg Mifepristone for oral administration once per day was provided，while in the observation group，half dose of Mifepristone in the control group was used once per day.The course of treatment was lasted for 6 months.The clinical curative effect，the changes of fibroid sizes，the level of estradiol （E2） and progesterone （P），the incidence rate of adverse reactions were compared between the two groups.Results The total clinical effective rate in the observation group was 96.67%，and 90.00% in the control group，there was no significant difference between the two groups （P0.05）.Compared with before treatment，the sizes of uterus and uterine fibroids after treatment in the two groups were both significantly reduced，with significant differences （P0.05）.The total incidence rate of adverse reactions like nausea，vomiting，and profuse sweating was 13.33%，which was lower than that in the control group accounting for 30.00%，with significant difference （P0.05）.Conclusion Compared with conventional dose，the effect on perimenopausal uterine