脑梗死二级预防中阿司匹林抵抗现象及干预措施分析.docVIP

精品论文 参考文献 脑梗死二级预防中阿司匹林抵抗现象及干预措施分析 （四川省德阳市中江县人民医院神经内科 四川 德阳 618100） 　　【摘要】 目的：分析研讨脑梗死二级预防中阿司匹林抵抗现象及干预措施。方法：此研究中所研讨的360例患者均随机选取于2015年1月-12月期间入院后接受阿司匹林治疗的脑梗死患者中，十天后测定患者血小板聚集率，挑选阿司匹林敏感者、半反应、抵抗者，随机将其分A（90例）、B（90例）、C（90例）三组，其余90例患者划分到D组，继续接受阿司匹林药物治疗，其随访时间为6个月，A组接受氯吡格雷药物治疗，B组加服用氯吡格雷，C组和D组则继续给予阿司匹林药物，观察并记录其心血管事件。结果：和换药前比较，A组血小板AA诱导聚集率明显要高，血小板聚集率ADP诱导出现明显性降低（Plt;0.05）；B组患者ADP诱导和AA诱导血小板聚集率都明显性降低（Plt;0.05）。和B、D组进行对比，A、C组患者发生缺血性事件率明显要高，组间数据有统计学意义（Plt;0.05）。结论：脑梗死二级预防中阿司匹林抵抗状况可将阿司匹林和氯吡格雷药物联合使用，此方式可将其抵抗现象改善，降低发生缺血性事件的可能性。 　　【关键词】 阿司匹林；脑梗死；心血管事件；二级预防；氯吡格雷 　　【中图分类号】R742 【文献标识码】A 【文章编号】2095-1752（2016）34-0023-02 　　Analysis of aspirin resistance and intervention measures in two level prevention of cerebral infarction Gong Lin, Duan Yong. 　　Zhongjiang County Peoples Hospital Neurology Deyang City of Sichuan Province, Sichuan Deyang, 618100, China 　　【Abstract】Objective To analyze and discuss the phenomenon of aspirin resistance and its intervention in the prevention of two levels of cerebral infarction. Methods This study in the research of 360 cases of patients, randomly divided a (90 cases), B (90 cases), C (90 cases) group, and the remaining 90 patients were divided into group D, continue to receive aspirin treatment, the follow-up time was 6 months, a group received clopidogrel treatment, B group with clopidogrel, C group and D group to continue to give aspirin to observe and record the cardiovascular events. Results Before dressing and platelet in group a AA induced aggregation rate is significantly higher, the platelet aggregation rate induced by ADP had significantly decreased (P lt; 0.05); in group B were ADP induced and AA induced platelet aggregation rate were significantly decreased (P lt; 0.05). Compared with B and D groups, the incidence of ischemic events was significantly higher in patients with A and C, and the data were statistically significant (Plt;0.05). Conclusion The aspirin resistance in the two level of cerebral inf