胸腔内注入顺铂联合白介素-Ⅱ治疗恶性胸腔积液疗效对比.docVIP

精品论文 参考文献 胸腔内注入顺铂联合白介素-Ⅱ治疗恶性胸腔积液疗效对比 李毅星 ( 南阳市第二人民医院肿瘤科 河南南阳 4 7 3 0 1 2 ) 【摘要】目的　探讨胸腔内注入顺铂(DD P)联合白介素Ⅱ(I L--Ⅱ)治疗恶性胸腔积液的疗效-。方法　病理确诊的恶性胸腔积液60例,经胸腔插管引流术排尽胸液后,按随机化原则分为2组,治疗组(32例)在胸腔内注入DDP50 mg/m2, IL--Ⅱ８０万ＩＵ,对照组(28例)在胸腔内注入DDP 50 mg/m2,1周后重复1次,观察疗效、生活质量、生存率以及毒副反应。结果　治疗组总有效率81%,病变进展率3%,较对照组50%,25%差异有显著性(Plt;0bull;05)。Karnofsky评分大于70分治疗组较对照组有显著提高(Plt;0bull;05)。治疗组0bull;5年、1年、1bull;5年、2年的生存率为97%、59%、44%、6%,分别高于对照组的71%、50%、14%、4%,其中0bull;5,1bull;5年的生存率差异有显著性(Plt;0bull;05)。治疗组Ⅰ度白细胞下降较对照组明显。结论　胸腔内联合注入DDP和IL--Ⅱ治疗恶性胸腔积液是一种有效的、副反应小、可耐受的方法。 【关键词】顺铂 白介素-Ⅱ 恶性胸腔积液 【中图分类号】R45 【文献标识码】A 【文章编号】2095-1752（2012）01-0379-02 Treatment of malignant pleural effusion using vindesine and cisplatine intrapleurally injection(observation of 60 cases) LI Yixing. Department Oncology Nanyang Second Peoples Hospital. 【Abstract】Objective　To evaluate the efficacy of treating malignant pleural effusion with cisplatine and IL--Ⅱ by injection through thoracic tube intubation.Methods　60 cases with malignant pleural effusion,after drainage, IL--Ⅱ８０万ＩＵ,cisplatine 50 mg/m2were injectred into pleural cavity in therapy group(T),and only cisplatine 50 mg/m2in control group (C)bull;thetretment was repeated after a week,then evaluate the efficacy,survival rate,toxicities and quality of life.Results　The response rate was 81% in T group and 50% in C groupbull;There was statistical difference in two groups (Plt;0bull;05)bull;The Karnofsky score is higher in Tgroup than in C groupbull;The half-year,one-year,one and half-year,two-year survival rateswere 97%,59%,44%,6% inTgroup and 71%,50%,14%,4% in C groupbull;Grade I leukopenia is higher in T group than in C group.Conclusion The treatment to use ８０万ＩＵand cisplatinethrough thoracic tube is regarded as effective,slight side-effect and welltolerated method for malignant pleural effusionbull; 【Key words】Cisplatine IL--Ⅱ Malignant pleural effusion 恶性胸腔积液约占整个胸腔积液的25%[1],是癌症晚期表现之一。自2007年起,我科在胸腔闭塞引流排尽胸液后,在胸腔内注射顺铂(D D P)以及联合白介素Ⅱ(IL--Ⅱ)治疗恶性胸腔积液作疗效比较,现将结果报告如下。材料与方法