瑞舒伐他汀对急性冠脉综合征患者动脉粥样硬化的疗效观察.docVIP

精品论文 参考文献 瑞舒伐他汀对急性冠脉综合征患者动脉粥样硬化的疗效观察 郭素萍1 刘畅 1 高传玉2（1郑州大学附属郑州中心医院急诊科 450007；2河南省人民医院心内科 450052） 【中图分类号】R972+.6 【文献标识码】A【文章编号】1672-5085（2012）50-0164-02 【摘要】 目的 观察瑞舒伐他汀对急性冠脉综合征患者颈动脉粥样硬化斑块的影响。方法 120例急性冠脉综合征患者合并颈动脉粥样斑块，随机分为阿托伐他汀组60例，瑞舒伐他汀组60例，随访6个月，观察血脂及血浆hs-C反应蛋白（hs-CPR）的水平，并测定颈动脉内膜中层厚度（IMT）的改变。结果 瑞舒伐他汀组及阿托伐他汀组患者治疗6个月后，总胆固醇(TC)、低密度脂蛋白（LDL-C）及hs-CPR均有明显下降（Plt;0.05）；高密度脂蛋白（HDL）在阿托伐他汀组无明显变化，瑞舒伐他汀组明显升高（Plt;0.05）。瑞舒伐他汀组患者治疗6个月后，颈动脉内膜中层厚度（IMT）明显下降（Plt;0.05），而阿托伐他汀组治疗6个月后，颈动脉内膜中层厚度（IMT）无明显变化。结论 瑞舒伐他汀在急性冠脉综合征患者中通过调脂及降hs-CPR，起到稳定逆转斑块的作用。 【关键词】瑞舒伐他汀 急性冠脉综合征 动脉粥样硬化 Curative effect of rosuvastatin on atherosclerotic plaques in patients with acute coronary syndrome GUOSu-ping;LIU Chang; GAO Chuanyu (1.Department of Emergency, Zhengzhou Central Hospital Affiliated to Zhengzhou University. Zhengzhou 450007, China. 2.Department of cardiology, Henan provincial Peoplersquo;s Hospital, 450007,China.) 【Abstract】Objective To explore the Curative effect of rosuvastatin on carotid atherosclerotic plaques in patients with acute coronary syndrome. Methods　120 patients of acute coronary syndrome with carotid atherosclerotic plaques were selected. They were divided into rosuvastatin group or atorvastatin group( for 6 months) at random. The serum levels of lipids,high-sensitivity C-reactive protein( hs-CRP) and carotid IMT were measured at the base line and 6 months after the treatment respectively. Results　 At the end of 6 months,the patients in atorvastatin group and rosuvastatin group showed significantly reduced total cholesterol,LDL-C and hs-CRP(Plt;0.05). The differences of HDL in atorvastatin group on admission was not significant(Pgt;0.05).Serum HDL level was significantly increased in rosuvastatin group(Plt;0.05).The intima media thickness (IMT)of the common carotid artery was reduced significantly after a 6-month rosuvastatin therapy（Plt;0.05）,but almost remained unchanged after atorvastatin therapy. Conclusion rosuvastatin therapy could