他汀类药物与感染发生率及死亡率关系的meta分析.pdfVIP

·988 · doi 10.3969/j.issn. 1673-4254.2014.07.15 J South Med Univ, 2014, 34(7): 988-993 临床研究 他汀类药物与感染发生率及死亡率关系的他汀类药物与感染发生率及死亡率关系的metameta分析分析 王贵佐，张永红，谢新明，韩 冬，吴媛媛，李少军，李凤娟，李满祥 西安交通大学第二附属医院呼吸病研究室//呼吸内科，陕西 西安 710004 摘要：目的 系统评价他汀类药物能否降低感染的风险及降低感染相关死亡率。方法 检索Cochrane 图书馆、MEDLINE、 EMBASE、PubMed、Elsevier数据库和中国生物医学文献数据库等从建库至2013年9月已完成的有关他汀的随机对照试验（至 少100位参与者，持续时间至少4周）。由2位研究者按照纳入标准独立筛选文献、提取资料和评价质量后，应用Stata 12.0 软件 进行荟萃分析。结果 纳入16个随机对照研究，共包括48973例研究对象。荟萃分析结果显示：与安慰剂组比较，他汀类药物 能显著降低感染风险（OR=0.93，95%可信区间0.89-0.98，P=0.004）。但是在改善感染相关死亡率方面，两组间无显著性差异 （OR=0.96，95%可信区间0.82-1.12，P=0.592）。结论 他汀类药物可显著降低感染的风险，但是不能降低感染相关死亡率。 关键词：他汀类药物；感染风险；感染相关死亡率；随机对照实验；荟萃分析 Effect of statins on occurrence of infection and infection-related mortality: a meta-analysis WANG Guizuo, ZHANG Yonghong, XIE Xinming, HAN Dong, WU Yuanyuan, LI Shaojun, LI Fengjuan, LI Manxiang Institute of Respiratory Medicine, Department of Respiratory Medicine, Second Affiliated Hospital, Xian Jiaotong University College of Medicine, Xian 710004, China Abstract: Objective To systematically review whether statins can reduce the risk of infection and infection-related mortality. Methods We searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow- up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software. Results Sixteen trails involving a total of 48973 patients were included in our meta- analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection- related mortality (OR=0.96,