组蛋白去乙酰化酶作为抗肿瘤药物的研究.pdfVIP

国内外抗肿瘤药物研发动态 组蛋白去乙酰化酶作为抗肿瘤药物的研究 New Histone Deacety lase Inhibitors AS A nti-Cancer Drugs 蒋晟 2012-11-09 Cancer is common Lifetime risk of cancer in human populations is around 1 out of 3 Each year 13 million cases are diagnosed Cancer is worsening in China, where it causes an annual 2.1 million deaths. What is Cancer? A problem of multicellular organisms Multicellularity requires social cohesion of cells: All cells must die at some point in multicellular organisms Cancer cells revert to unicellular selfishness, and are immortal, and fail to die 抗肿瘤药物的发展历史 年代 代表性药物 1940s 氮芥、甲氨蝶呤、秋水仙碱、已烯雌酚、雌激素、睾酮 1950s 环磷酰胺、氟尿嘧啶、白消安、苯丁酸氮芥、碘解磷定、塞替 派、丝裂霉素、放线菌素D、巯嘌呤、长春碱、秋裂胺、多聚 脱氧核糖核苷 1960s1960s 甲氧芳芥甲氧芳芥、、硝卡芥硝卡芥、、异芳芥异芳芥、、亚亚胺醌胺醌、、丙丙卡卡巴肼巴肼、、链黑链黑霉素霉素、、 博来霉素、柔红霉素、多柔比星、羟基脲、 糖胞苷、达卡巴 嗪、门冬酰胺酶、硫鸟嘌呤、长春新碱、抗肿瘤锑、美法仑 1970s 顺铂、 霉素、喜树碱、卡莫司汀、洛莫司汀、司莫司汀、链 佐星、普卡霉素、安西他滨、丙亚胺、嘧啶苯芥、三尖杉碱、 高三尖杉酯碱、替尼泊苷、依托泊苷、左旋咪唑、泰洛龙 1980s 柔比星、表柔比星、长春地辛、卡铂、替加氟、优福定、长 春瑞滨、卡莫氟、异环磷酰胺 1990s 紫杉醇类、吡曲克辛、伊立替康、托泊替康、吉西他滨、吡柔 比星、维A 酸、奥沙利泊、卡培他滨、 2000s 靶向治疗药物 为了帮助保护您的隐私，PowerPoint 禁止自动下载此外部图片。若要下载并显示此图片，请单击消息栏中的 选项”，然后单击 启用外部内容”。 1.最初的抗肿瘤药物(1940-1952) a.氮芥(Goodman and Gilman )用于治疗淋巴癌 b.甲氨蝶呤(抗叶酸合成)用于治疗急性粒细胞白血病, 1948 Sidney Farbers work was instrumental in showing that effective pharmacological ttreareattmemenntt o off cacanncercer wwasas popossssibliblee,, aandnd ttoo tthihiss