detailed analysis of variants in fto in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly详细的分析变异在fto协会与身体组成的70岁的建议中老年人削弱的影响.pdfVIP
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detailed analysis of variants in fto in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly详细的分析变异在fto协会与身体组成的70岁的建议中老年人削弱的影响
Detailed Analysis of Variants in FTO in Association with Body Composition in a Cohort of 70-Year-Olds Suggests a Weakened Effect among Elderly 1 ¨ ´ 1 1 2 Josefin A. Jacobsson , Markus Sallman Almen , Christian Benedict , Lilia A. Hedberg , Karl ¨ 3 1 5 4 5,6 ˚ ¨ 5 Michaelsson , Samantha Brooks , Joel Kullberg , Tomas Axelsson , Lars Johansson , Hakan Ahlstrom , 1 4 ¨ 1 Robert Fredriksson , Lars Lind , Helgi B. Schioth * 1 Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden, 2 Science for Life Laboratory, Royal Institute of Technology (KTH), School of Biotechnology, Solna, Sweden, 3 Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, 4 Department of Medical Sciences, Uppsala University, ¨ ¨ Uppsala, Sweden, 5 Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, 6 AstraZeneca RD Molndal, Molndal, Sweden Abstract Background: The rs9939609 single-nucleotide polymorphism (SNP) in the fat mass and obesity (FTO) gene has previously been associated with higher BMI levels in children and young adults. In contrast, this association was not found in elderly men. BMI is a measure of overweight in relation to the individuals’ height, but offers no
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