designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin设计的降解酶的抑制剂调节胰岛素的分解代谢和活动.pdfVIP

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designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin设计的降解酶的抑制剂调节胰岛素的分解代谢和活动.pdf

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designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin设计的降解酶的抑制剂调节胰岛素的分解代谢和活动

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin 1,2,3 4 1 1 1 Malcolm A. Leissring *, Enrico Malito , Sabrine Hedouin , Lael Reinstatler , Tomoko Sahara , Samer O. 1 1 1 1 2 Abdul-Hay , Shakeel Choudhry , Ghulam M. Maharvi , Abdul H. Fauq , Malwina Huzarska , Philip S. 2 5 3 6 7 4 May , Sungwoon Choi , Todd P. Logan , Benjamin E. Turk , Lewis C. Cantley , Marika Manolopoulou , 4 5 5 3 Wei-Jen Tang , Ross L. Stein , Gregory D. Cuny , Dennis J. Selkoe 1 Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America, 2 Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America, 3 Center for Neurologic Diseases, Brigham Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 4 Ben-May Institute for Cancer Research, University of Chicago, Chicago, Illinois, United States of America, 5 Laboratory for Drug Discovery in Neurodegeneration, Brigham Women’s Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America, 6 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America, 7 Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of Ameri