depletion of b2 but not b1a b cells in baff receptor-deficient apoe？？ mice attenuates atherosclerosis by potently ameliorating arterial inflammationb2损耗,但不缺少高飞球的一击b1a b细胞受体的apoe们注入了 老鼠变弱的动脉粥样硬化有说服力地改善动脉炎症.pdfVIP

Depletion of B2 but Not B1a B Cells in BAFF Receptor- Deficient ApoE2/ 2 Mice Attenuates Atherosclerosis by Potently Ameliorating Arterial Inflammation 1,2 1,2 1,2 1 1 Tin Kyaw *, Christopher Tay , Hamid Hosseini , Peter Kanellakis , Tahlia Gadowski , Fabeinne 3 2 1. 2. MacKay , Peter Tipping , Alex Bobik , Ban-Hock Toh 1Vascular Biology and Atherosclerosis Laboratory, Baker IDI Heart and Diabetes Institute, Victoria, Australia, 2 Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia, 3 Department of Immunology, Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia Abstract We have recently identified conventional B2 cells as atherogenic and B1a cells as atheroprotective in hypercholesterolemic ApoE2/ 2 mice. Here, we examined the development of atherosclerosis in BAFF-R deficient ApoE2/ 2 mice because B2 cells but not B1a cells are selectively depleted in BAFF-R deficient mice. We fed BAFF-R2/ 2 ApoE2/ 2 (BaffR.ApoE DKO) and BAFF- R+/+ApoE2/ 2 (ApoE KO) mice a high fat diet (HFD) for 8-weeks. B2 cells were significantly reduced by 82%, 81%, 94%, 72% in blood, peritoneal fluid, spleen and peripheral lymph nodes respectively; while B1a cells and non-B lymphocytes were unaffected. Aortic atherosclerotic lesions assessed by oil red-O stained-lipid accumulation and CD68+ macrophage accumulation were decreased by 44% and 50% respectively. B cells were absent in atherosclerotic lesions of BaffR.ApoE DKO mice as were IgG1 and