有哪些信誉好的足球投注网站depletion of cellular pre-replication complex factors results in increased human cytomegalovirus dna replication损耗的细胞pre-replication复杂因素导致增加人类巨细胞病毒dna复制.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
depletion of cellular pre-replication complex factors results in increased human cytomegalovirus dna replication损耗的细胞pre-replication复杂因素导致增加人类巨细胞病毒dna复制
Depletion of Cellular Pre-Replication Complex Factors Results in Increased Human Cytomegalovirus DNA Replication Tamara Evans Braun., Emma Poole., John Sinclair* Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom Abstract Although HCMV encodes many genes required for the replication of its DNA genome, no HCMV-encoded orthologue of the origin binding protein, which has been identified in other herpesviruses, has been identified. This has led to speculation that HCMV may use other viral proteins or possibly cellular factors for the initiation of DNA synthesis. It is also unclear whether cellular replication factors are required for efficient replication of viral DNA during or after viral replication origin recognition. Consequently, we have asked whether cellular pre-replication (pre-RC) factors that are either initially associated with cellular origin of replication (e.g. ORC2), those which recruit other replication factors (e.g. Cdt1 or Cdc6) or those which are subsequently recruited (e.g. MCMs) play any role in the HCMV DNA replication. We show that whilst RNAi-mediated knock-down of these factors in the cell affects cellular DNA replication, as predicted, it results in concomitant increases in viral DNA replication. These data show that cellular factors which initiate cellular DNA synthesis are not required for the initiation of replication of viral DNA and suggest that inhibition of cellular DNA synthesis, in itself, fosters conditions which are conducive to viral DNA replication. Citation: Evans Braun T, Poole E, Sinclair J (2012) Depletion of Cellular Pre-Replication Complex Factors Results in Increased Human Cytomegalovirus DNA Replication. PLoS ONE 7(5): e36057. doi:10.1371/journal.pone.0036057 Editor: Maria G. Masucci, Karolinska Institutet, Sweden Received October 5, 20
您可能关注的文档
- deficits in long-term recognition memory reveal dissociated subtypes in congenital prosopagnosia赤字长期识别记忆显示分离亚型在先天性面容失认症.pdf
- defining the functional domain of programmed cell death 10 through its interactions with phosphatidylinositol-3,4,5-trisphosphate定义的功能域程序性细胞死亡10与phosphatidylinositol-3交互,4,5-trisphosphate.pdf
- defining components of the ？catenin destruction complex and exploring its regulation and mechanisms of action during development定义组件的连环蛋白破坏复杂并探索其在开发过程中调控和作用机制.pdf
- definition of microscopic tumor clearance (r0) in pancreatic cancer resections定义的微观间隙(r0)在胰腺癌肿瘤切除术.pdf
- defining the true sensitivity of culture for the diagnosis of melioidosis using bayesian latent class models定义真正的文化敏感性的诊断类鼻疽使用贝叶斯潜在的类模型.pdf
- defining the specificity of cotranslationally acting chaperones by systematic analysis of mrnas associated with ribosome-nascent chain complexes定义的特异性cotranslationally代理监护人mrna的系统分析与ribosome-nascent链复合物.pdf
- defining the boundaries of normal thrombin generation investigations into hemostasis定义的边界正常止血凝血酶生成调查.pdf
- defining the sister rat mammary tumor cell lines hh-16 cl.21 and hh-16.cl.4 as an in vitro cell model for erbb2定义妹妹大鼠乳腺肿瘤细胞株hh-16 cl。.pdf
- deformed epidermal autoregulatory factor-1 (deaf1) interacts with the ku70 subunit of the dna-dependent protein kinase complex变形表皮自身调节的因子- 1(deaf1)与ku70单元交互依赖dna的蛋白激酶的复杂.pdf
- deformed generalization of the semiclassical entropy变形泛化的半古典的熵.pdf
- depauperate avifauna in plantations compared to forests and exurban areas发育不全的种植园相比,森林和远郊地区的鸟类.pdf
- dengue virus ensures its fusion in late endosomes using compartment-specific lipids登革病毒确保其融合在后期使用compartment-specific脂质核内体.pdf
- depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis损耗的树突细胞增强先天抗菌宿主防御通过调制的吞噬细胞内稳态.pdf
- depletion of cytotoxic t-cells does not protect nup98-hoxd13 mice from myelodysplastic syndrome but reveals a modest tumor immunosurveillance effect损耗的细胞毒性t细胞不保护nup98-hoxd13小鼠骨髓增生异常综合征,但揭示了一个温和的肿瘤免疫监视作用.pdf
- depletion of hdac6 enhances cisplatin-induced dna damage and apoptosis in non-small cell lung cancer cells损耗的hdac6增强cisplatin-induced dna损伤,在非小细胞肺癌细胞凋亡.pdf
- depletion of plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite损耗的鼠plasmoredoxin揭示了一个不必要的疟疾寄生虫的生命周期发展的角色.pdf
- depolarization-evoked secretion requires two vicinal transmembrane cysteines of syntaxin 1adepolarization-evoked分泌需要两个附近的1突触融合蛋白的跨膜半胱氨酸.pdf
- depolarization and cam kinase iv modulate nmda receptor splicing through two essential rna elements去极化和凸轮第四激酶调节门冬氨酸受体通过两个重要rna拼接元素.pdf
- depletion of the c. elegans nac engages the unfolded protein response, resulting in increased chaperone expression and apoptosis损耗的秀丽隐杆线虫nac展开的蛋白质反应,导致增加伴侣蛋白表达和细胞凋亡.pdf
- deoxyamphimedine, a pyridoacridine alkaloid, damages dna via the production of reactive oxygen speciesdeoxyamphimedine pyridoacridine生物碱,损害dna通过活性氧的生产.pdf
文档评论（0）