有哪些信誉好的足球投注网站defining components of the ？catenin destruction complex and exploring its regulation and mechanisms of action during development定义组件的连环蛋白破坏复杂并探索其在开发过程中调控和作用机制.pdfVIP
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defining components of the ？catenin destruction complex and exploring its regulation and mechanisms of action during development定义组件的连环蛋白破坏复杂并探索其在开发过程中调控和作用机制
Defining Components of the ßcatenin Destruction Complex and Exploring Its Regulation and Mechanisms of Action during Development 1,2,3 4 1 5 1,2 David M. Roberts *, Mira I. Pronobis , Kelly M. Alexandre , Gregory C. Rogers , John S. Poulton , 1 1 1 1,2,4 Daniel E. Schneider , Kuo-Chen Jung , Daniel J. McKay , Mark Peifer * 1 Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 2 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 3 Department of Biology, Franklin and Marshall College, Lancaster, Pennsylvania, United States of America, 4 Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 5 Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, United States of America Abstract Background: A subset of signaling pathways play exceptionally important roles in embryonic and post-embryonic development, and mis-regulation of these pathways occurs in most human cancers. One such pathway is the Wnt pathway. The primary mechanism keeping Wnt signaling off in the absence of ligand is regulated proteasomal destruction of the canonical Wnt effector ßcatenin (or its fly homolog Armadillo). A substantial body of evidence indicates that SCFbTrCP mediates bcat destruction, however, an essential role for Roc1 has not been dem
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