有哪些信誉好的足球投注网站crucial role of heme oxygenase-1 on the sensitivity of cholangiocarcinoma cells to chemotherapeutic agents关键作用的血红素oxygenase-1胆管细胞型肝癌细胞对化疗药物的敏感性.pdfVIP
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crucial role of heme oxygenase-1 on the sensitivity of cholangiocarcinoma cells to chemotherapeutic agents关键作用的血红素oxygenase-1胆管细胞型肝癌细胞对化疗药物的敏感性
Crucial Role of Heme Oxygenase-1 on the Sensitivity of Cholangiocarcinoma Cells to Chemotherapeutic Agents 1 1,3 1,3 1,3 Sarinya Kongpetch , Veerapol Kukongviriyapan *, Auemduan Prawan , Laddawan Senggunprai , Upa Kukongviriyapan2, Benjaporn Buranrat4 1 Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 2 Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 3 Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, Khon Kaen, Thailand, 4 Faculty of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand Abstract Cancer cells acquire drug resistance via various mechanisms including enhanced cellular cytoprotective and antioxidant activities. Heme oxygenase-1 (HO-1) is a key enzyme exerting potent cytoprotection, cell proliferation and drug resistance. We aimed to investigate roles of HO-1 in human cholangiocarcinoma (CCA) cells for cytoprotection against chemotherapeutic agents. KKU-100 and KKU-M214 CCA cell lines with high and low HO-1 expression levels, respectively, were used to evaluate the sensitivity to chemotherapeutic agents, gemcitabine (Gem) and doxorubicin. Inhibition of HO-1 by zinc protoporphyrin IX (ZnPP) sensitized both cell types to the cytotoxicity of chemotherapeutic agents. HO-1 gene silencing by siRNA validated the cytoprotective effect of HO-1 on CCA cells against Gem. Induction of HO-1 protein expression by stannous chloride enhanced the cytoprotection and suppression of apoptosis caused by anticancer agents. The sensitizing effect of ZnPP was associated with increa
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