daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid contententerococci daptomycin电阻是与不同的细胞膜磷脂含量变化有关.pdfVIP
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daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid contententerococci daptomycin电阻是与不同的细胞膜磷脂含量变化有关
Daptomycin Resistance in Enterococci Is Associated with Distinct Alterations of Cell Membrane Phospholipid Content 1 1,2 3,4 5 6 Nagendra N. Mishra , Arnold S. Bayer , Truc T. Tran , Yousif Shamoo , Eugenia Mileykovskaya , 6 7 3,8 William Dowhan , Ziqiang Guan , Cesar A. Arias * 1 Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, California, United States of America, 2 David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America, 3 Division of Infectious Disease, Laboratory for Antimicrobial Research, University of Texas Medical School at Houston, Houston, Texas, United States of America, 4 University of Houston College of Pharmacy, Houston, Texas, United States of America, 5 Department of Biochemistry and Cell Biology, and Department of Ecology and Evolutionary Biology, Rice University, Houston, Texas, United States of America, 6 Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, Texas, United States of America, 7 Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America, 8 Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque, Bogota, Colombia Abstract Background: The lipopeptide antibiotic, daptomycin (DAP) interacts with the bacterial cell membrane (CM). Development of DAP resistance during therapy in a clinical strain of Enterococcus faecalis was associated with mutations in genes encoding enzymes involved in cell
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