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cytoskeletal components of an invasion machine—the apical complex of toxoplasma gondii细胞骨架的组成部分入侵分析复杂刚地弓形虫的顶端.pdf

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cytoskeletal components of an invasion machine—the apical complex of toxoplasma gondii细胞骨架的组成部分入侵分析复杂刚地弓形虫的顶端

Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii 1 1 2 3 4 5 1 Ke Hu , Jeff Johnson , Laurence Florens , Martin Fraunholz , Sapna Suravajjala , Camille DiLullo , John Yates , 4 6* David S. Roos , John M. Murray 1 Department of Cell Biology, Scripps Research Institute, La Jolla, California, United States of America, 2 The Stowers Institute for Medical Research, Kansas City, Missouri, United States of America, 3 Institute of Microbiology, E.-M.-Arndt University, Greifswald, Germany, 4 Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 5 Department of Anatomy, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, United States of America, 6 Department of Cell Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The understanding of apical complex function, the basis for its novel structure, and the mechanism for its motility are greatly impeded by lack of knowledge of its molecular composition. We have partially purified the conoid/apical complex, identified ;200 proteins that represent 70% of its cytoskeletal protein components, characterized seven novel proteins, and determined the sequence of recruitment of five of these proteins into the cytoskeleton during cell division. Our results provide new markers for the different subcompartments within the apical complex, and revealed previously unknown cellular compartments, which facilitate our understanding of ho