cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol细胞毒性的半合成衍生物elatol isoobtusol.pdfVIP

Mar. Drugs 2012, 10, 2254-2264; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol and Isoobtusol Karen L. Lang 1,*, Izabella T. Silva 1, Lara A. Zimmermann 1, Cíntia Lhullier 1, 2 2 1 1 Maria V. Mañalich Arana , Jorge A. Palermo , Miriam Falkenberg , Cláudia M. O. Simões , 1 2 Eloir P. Schenkel and Fernando J. Durán 1 Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-970, Brazil; E-Mails: izabellathais@ (I.T.S.); lalinhazi@ (L.A.Z.); clhullier@.br (C.L.); miriam@ccs.ufsc.br (M.F.); claudias@reitoria.ufsc.br (C.M.O.S.); eloirschenkel@ (E.P.S.) 2 Department of Organic Chemistry, University of Buenos Aires, Buenos Aires, C1428EGA, Argentina; E-Mails: vmanalich@qo.fcen.uba.ar (M.V.M.A.); palermo@qo.fcen.uba.ar (J.A.P.); fduran@qo.fcen.uba.ar (F.J.D.) * Author to whom correspondence should be addressed; E-Mail: karenluise@; Tel.: +55-48 Fax: +55-48 Received: 1 August 2012; in revised form: 12 September 2012 / Accepted: 1 October 2012 / Published: 18 October 2012 Abstract: In the present study, the in vitro cytotoxic effects of six semi-synthetic derivatives of elatol (1) and isoobtusol (2) were investigated. Chemical modifications were performed on the hydroxyl groups aiming to get