cytoplasmic plaque formation in hemidesmosome development is dependent on soxf transcription factor function胞质空斑形成半桥粒的发展依赖于soxf转录因子的功能.pdfVIP

Cytoplasmic Plaque Formation in Hemidesmosome Development Is Dependent on SoxF Transcription Factor Function 1 2 1 2 1 Shelly Oommen , Mathias Francois , Maiko Kawasaki , Melanie Murrell , Katsushige Kawasaki , 1 1 2 3 4 Thantrira Porntaveetus , Sarah Ghafoor , Neville J. Young , Yoshimasa Okamatsu , John McGrath , 2 1 1,3 Peter Koopman , Paul T. Sharpe , Atsushi Ohazama * 1 Craniofacial Development and Stem Cell Biology, and Biomedical Research Centre, Dental Institute, King’s College London, London, United Kingdom, 2 Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia, 3 Department of Periodontology, Showa University Dental School, Tokyo, Japan, 4 Genetic Skin Disease Group, St John’s Institute of Dermatology, Division of Skin Sciences, King’s College London, London, United Kingdom Abstract Hemidesmosomes are composed of intricate networks of proteins, that are an essential attachment apparatus for the integrity of epithelial tissue. Disruption leads to blistering diseases such as epidermolysis bullosa. Members of the Sox gene family show dynamic and diverse expression patterns during development and mutation analyses in humans and mice provide evidence that they play a remarkable variety of roles in development and human disease. Previous studies have established that the mouse mutant ragged-opossum (Raop) expresses a dominant-negative form of the SOX18 transcription factor that interferes with the function of wild type SOX18 and of the related