cord blood glutathione depletion in preterm infants correlation with maternal cysteine depletion脐带血中谷胱甘肽耗竭与孕产妇半胱氨酸早产儿相关损耗.pdfVIP

Cord Blood Glutathione Depletion in Preterm Infants: Correlation with Maternal Cysteine Depletion ¨ 1,2 3 ´ 5 3 3 Alice Kuster , Illa Tea , Veronique Ferchaud-Roucher , Sabrina Le Borgne , Claire Plouzennec , Norbert 1,4 ´ 1,2 3 1,6 Winer , Jean-Christophe Roze , Richard J. Robins , Dominique Darmaun * ´ 1 UMR Physiologie des Adaptations Nutritionnelles, INRA, Universite de Nantes, Nantes, France, 2 Division of Neonatology, CHU de Nantes INSERM, Centre ´ d’Investigation Clinique, Nantes, France, 3 CNRS, CEISAM, UMR 6230, Universite de Nantes, France, 4 Division of Obstetrics, CHU de Nantes, INSERM, Centre d’Investigation Clinique, Nantes, France, 5 Mass Spectrometry Core Facility, CRNH, Nantes, France, 6 Research Laboratory, Nemours Children’s Clinic, Jacksonville, Florida, United States of America Abstract Background: Depletion of blood glutathione (GSH), a key antioxidant, is known to occur in preterm infants. Objective: Our aim was to determine: 1) whether GSH depletion is present at the time of birth; and 2) whether it is associated with insufficient availability of cysteine (cys), the limiting GSH precursor, or a decreased capacity to synthesize GSH. Methodology: Sixteen mothers delivering very low birth weight infants (VLBW), and 16 mothers delivering healthy, full term neonates were enrolled. Immediately after birth, erythrocytes from umbilical vein, umbilical artery, and mater