computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton implications for side effects of general anesthesia计算预测的挥发性麻醉剂与微管细胞骨架的交互对全身麻醉的副作用的影响.pdfVIP

Computational Predictions of Volatile Anesthetic Interactions with the Microtubule Cytoskeleton: Implications for Side Effects of General Anesthesia 1 2 3 1 Travis J. A. Craddock *, Marc St. George , Holly Freedman , Khaled H. Barakat , 2,5 4 1,5 Sambasivarao Damaraju , Stuart Hameroff , Jack A. Tuszynski * 1 Department of Physics, University of Alberta, Edmonton, Alberta, Canada, 2 Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada, 3 Center of Marine Sciences, Foundation for Science and Technology, University of Algarve, Campus Gambelas, Faro, Portugal, 4 Departments of Anesthesiology and Psychology, Center for Consciousness Studies, The University of Arizona Health Sciences Center, Tucson, Arizona, United States of America, 5 Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada Abstract The cytoskeleton is essential to cell morphology, cargo trafficking, and cell division. As the neuronal cytoskeleton is extremely complex, it is no wonder that a startling number of neurodegenerative disorders (including but not limited to Alzheimer’s disease, Parkinson’s disease and Huntington’s disease) share the common feature of a dysfunctional neuronal cytoskeleton. Recently, concern has been raised about a possible link between anesthesia, post-operative cognitive dysfunction, and the exacerbation of neurodegenerative disorders. Experimental investigations suggest that anesthetics bind to and affect cytoskeletal