correlation analysis of cocoa consumption data with worldwide incidence rates of testicular cancer and hypospadias可可消费数据的相关分析与世界范围内的睾丸癌发病率和尿道下裂.pdfVIP
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correlation analysis of cocoa consumption data with worldwide incidence rates of testicular cancer and hypospadias可可消费数据的相关分析与世界范围内的睾丸癌发病率和尿道下裂
Int. J. Environ. Res. Public Health 2009, 6, 568-578; doi:10.3390/ijerph6020578 OPEN ACCESS International Journal of Environmental Research and Public Health ISSN 1660-4601 /journal/ijerph Article Correlation Analysis of Cocoa Consumption Data with Worldwide Incidence Rates of Testicular Cancer and Hypospadias Fabrizio Giannandrea Industrial and Environmental Hygiene Unit, Department of Animal and Human Biology, University “Sapienza”, Rome, Italy. E-mail: fabrizio.giannandrea@uniroma1.it; Tel.: +39-06 Fax: +39-06 Received: 31 December 2008 / Accepted: 2 February 2009/ Published: 5 February 2009 Abstract: The underlying reasons for the increasing occurrence of male reproductive diseases (MRD) such as hypospadias, cryptorchidism, and testicular cancer (TC) over the last decades are still unknown. It has been hypothesized that the risk of MRD is determined in utero and that pregnancy dietary intake could also affect MRD risk in the offspring. Various studies in animals reported that cocoa and theobromine, the main stimulant of cocoa, exert toxic effects on the testis, inducing testicular atrophy and impaired sperm quality. A correlation analysis was conducted to examine the possible role of cocoa consumption on the occurren
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