有哪些信誉好的足球投注网站computational study of hippocampal-septal theta rhythm changes due to beta-amyloid-altered ionic channels由于beta-amyloid-altered hippocampal-septalθ节律变化的计算研究离子通道.pdfVIP
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computational study of hippocampal-septal theta rhythm changes due to beta-amyloid-altered ionic channels由于beta-amyloid-altered hippocampal-septalθ节律变化的计算研究离子通道
Computational Study of Hippocampal-Septal Theta Rhythm Changes Due to Beta-Amyloid-Altered Ionic Channels Xin Zou*, Damien Coyle, KongFatt Wong-Lin, Liam Maguire Intelligent Systems Research Centre, University of Ulster Magee Campus, Derry, Northern Ireland, United Kingdom Abstract Electroencephagraphy (EEG) of many dementia patients has been characterized by an increase in low frequency field potential oscillations. One of the characteristics of early stage Alzheimer’s disease (AD) is an increase in theta band power (4–7 Hz). However, the mechanism(s) underlying the changes in theta oscillations are still unclear. To address this issue, we investigate the theta band power changes associated with b-Amyloid (Ab) peptide (one of the main markers of AD) using a computational model, and by mediating the toxicity of hippocampal pyramidal neurons. We use an established biophysical hippocampal CA1-medial septum network model to evaluate four ionic channels in pyramidal neurons, which were demonstrated to be affected by Ab. They are the L-type Ca2+ channel, delayed rectifying K+ channel, A-type fast-inactivating K+ channel and large-conductance Ca2+-activated K+ channel. Our simulation results demonstrate that only the Ab inhibited A-type fast-inactivating K+ channel can induce an increase in hippocampo-septal theta band power, while the other channels do not affect theta rhythm. We further deduce that this increased theta band power is due to enhanced synchrony of the pyramidal neurons. Our research may elucidate potential biomarkers and therapeutics for AD. Further investigation will be helpful for better understanding of AD-induced theta rhythm abnormalities and associated cognitive deficits. Citation: Zou X, Coyle D, Wong-Lin K, Maguire L (2011) Computational Study of Hippocampal-Septal Theta Rhythm Changes Due
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