correlated alterations in serotonergic and dopaminergic modulations at the hippocampal mossy fiber synapse in mice lacking dysbindin相关改变羟色胺和多巴胺能调节海马苔藓纤维突触小老鼠体内缺乏营养.pdfVIP

Correlated Alterations in Serotonergic and Dopaminergic Modulations at the Hippocampal Mossy Fiber Synapse in Mice Lacking Dysbindin 1,2 3 3,4 4 Katsunori Kobayashi *, Satomi Umeda-Yano , Hidenaga Yamamori , Masatoshi Takeda , Hidenori Suzuki1,2, Ryota Hashimoto2,4,5 1 Department of Pharmacology, Nippon Medical School, Tokyo, Japan, 2 Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Kawaguchi, Saitama, Japan, 3 Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 4 Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 5 Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Suita, Osaka, Japan Abstract Dysbindin-1 (dystrobrevin-binding protein 1, DTNBP1) is one of the promising schizophrenia susceptibility genes. Dysbindin protein is abundantly expressed in synaptic regions of the hippocampus, including the terminal field of the mossy fibers, and this hippocampal expression of dysbindin is strongly reduced in patients with schizophrenia. In the present study, we examined the functional role of dysbindin in hippocampal mossy fiber-CA3 synaptic transmission and its modulation using the sandy mouse, a spontaneous mutant with deletion in the dysbindin gene. Electrophysiological recordings were made in hippocampal slices prepared from adult male sandy mice and their wild-type littermates. Basic properties of the mossy fiber synaptic transmission in the mutant mice were generally normal except for slightly reduced frequency facilitation. Serotonin and dopamine, two ma