computational modeling of fluid flow and intra-ocular pressure following glaucoma surgery计算模型的流体流动和青光眼手术后眼内压力.pdfVIP

Computational Modeling of Fluid Flow and Intra-Ocular Pressure following Glaucoma Surgery 1 1 2 2 Bruce S. Gardiner *, David W. Smith , Michael Coote , Jonathan G. Crowston 1 School of Computer Science and Software Engineering, The University of Western Australia, Crawley, Western Australia, Australia, 2 Centre for Eye Research Australia (CERA), The University of Melbourne and the Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia Abstract Background: Glaucoma surgery is the most effective means for lowering intraocular pressure by providing a new route for fluid to exit the eye. This new pathway is through the sclera of the eye into sub-conjunctival tissue, where a fluid filled bleb typically forms under the conjunctiva. The long-term success of the procedure relies on the capacity of the sub-conjunctival tissue to absorb the excess fluid presented to it, without generating excessive scar tissue during tissue remodeling that will shut-down fluid flow. The role of inflammatory factors that promote scarring are well researched yet little is known regarding the impact of physical forces on the healing response. Methodology: To help elucidate the interplay of physical factors controlling the distribution and absorption of aqueous humor in sub-conjunctival tissue, and tissue remodeling, we have developed a computational model of fluid production in the eye and removal via the trabecular/uveoscleral pathways and the surgical pathway. This surgical pathway is then linked to a porous media computational model of a fluid bleb positioned within the sub-conjunctival tissue. The computational analysis is centered on typical functioning bleb geometry found in a human eye following glaucoma surgery. A parametric study is conducted of changes in