concurrence of danish dementia and cataract insights from the interactions of dementia associated peptides with eye lens α-crystallin合作互动的丹麦痴呆和白内障的见解与晶状体α-crystallin痴呆相关的肽.pdfVIP

Concurrence of Danish Dementia and Cataract: Insights from the Interactions of Dementia Associated Peptides with Eye Lens a-Crystallin 1. 2. 1 3 3 Ira Surolia , Sharmistha Sinha , Debi Prasad Sarkar , P. Yadagiri Reddy , G. Bhanuprakash Reddy , Avadhesha Surolia2,4* 1 Department of Biochemistry, South Campus, Delhi University, New Delhi, India, 2 Molecular Biophysics Unit, Indian Institute of Science, Bnaglore, India, 3 National Institute of Nutrition, Jamai-Osmania, Hyderabad, India, 4 National Institute of Immunology, Aruna Asafali Marg, New Delhi, India Abstract Familial Danish Dementia (FDD) is an autosomal disease, which is distinguished by gradual loss of vision, deafness, progressive ataxia and dementia. Cataract is the first manifestation of the disease. In this article, we demonstrate a specific correlation between the poisoning of the chaperone activity of the rat eye lens a-crystallins, loss of lens transparency in organ culture by the pathogenic form of the Danish dementia peptide, i.e. the reduced Danish dementia peptide (redADan peptide), by a combination of ex vivo, in vitro, biophysical and biochemical techniques. The interaction of redADan peptide and lens crystallins are very specific when compared with another chaperone, HSP-70, underscoring the specificity of the pathogenic form of Danish dementia peptide, redADan, for the early onset of cataract in this disease. Citation: Surolia I, Sinha S, Sarkar DP, Reddy PY, Reddy GB, et al. (2008) Concurrence of Danish Dementia and Cataract: Insights from the Interactions of Dementia Associated Peptides with Eye Lens a-Crystallin. PLoS ONE 3(8): e2927. doi:10.1371/journal.pone.0002927 Editor: Edathara Abraham, Universit