concurrent proinflammatory and apoptotic activity of a helicobacter pylori protein (hp986) points to its role in chronic persistence并发促炎和凋亡活性幽门螺旋杆菌蛋白(hp986)指向它的角色在慢性的持久性.pdfVIP

Concurrent Proinflammatory and Apoptotic Activity of a Helicobacter pylori Protein (HP986) Points to Its Role in Chronic Persistence 1 2 1,3 1 2 Ayesha Alvi , Suhail A. Ansari , Nasreen Z. Ehtesham , Mohammed Rizwan , Savita Devi , Leonardo A. 4 5 1,6 1,2,7 Sechi , Insaf A. Qureshi , Seyed E. Hasnain , Niyaz Ahmed * 1 Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, India, 2 Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India, 3 National Institute of Nutrition, Hyderabad, India, 4 Department of Biomedical Sciences, University of Sassari, Sassari, Italy, 5 Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India, 6 School of Biological Sciences, Indian Institute of Technology, Hauz Khas, New Delhi, India, 7 Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia Abstract Helicobacter pylori induces cytokine mediated changes in gastroduodenal pathophysiology, wherein, the activated macrophages at the sub-mucosal space play a central role in mounting innate immune response against the antigens. The bacterium gains niche through persistent inflammation and local immune-suppression causing peptic ulcer disease or chronic gastritis; the latter being a significant risk factor for the development of gastric adenocarcinoma. What favors persistence of H. pylori in the gastric niches is not clearly understood. We report detailed characterization of a functionally unknown gene (HP986),