有哪些信誉好的足球投注网站components of cell-matrix linkage as potential new markers for prostate cancercell-matrix链接的组件作为前列腺癌的潜在的新标记.pdfVIP
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components of cell-matrix linkage as potential new markers for prostate cancercell-matrix链接的组件作为前列腺癌的潜在的新标记
Cancers 2011, 3, 883-896; doi:10.3390/cancers3010883 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Components of Cell-Matrix Linkage as Potential New Markers for Prostate Cancer Alexey Navdaev and Johannes A. Eble * Center for Molecular Medicine, Deptartment Vascular Matrix Biology, Excellence Cluster Cardio- Pulmonary System, Frankfurt University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany; E-Mail: navdaev@med.uni-frankfurt.de * Author to whom correspondence should be addressed; E-Mail: eble@med.uni-frankfurt.de; Tel.: +49 69 6301 87651; Fax: +49 69 6301 87656. Received: 25 January 2011; in revised form: 12 February 2011 / Accepted: 17 February 2011 / Published: 25 February 2011 Abstract: Prostate cancer is one of the most common tumor diseases worldwide. Often being non-aggressive, prostate tumors in these cases do not need immediate treatment. However, about 20% of diagnosed prostate cancers tend to metastasize and require treatment. Existing diagnostic methods may fail to accurately recognize the transition of a dormant, non-aggressive tumor into highly malignant prostate cancer. Therefore, new diagnostic tools are needed to improve diagnosis and therapy of prostate carcinoma. This review evaluates existing methods to diagnose prostate carcinoma, such as the biochemical marker prostate-specific antigen (PSA), but also discusses the possibility to use the altered expression of integrins and laminin-332
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