comparative genome analysis of filamentous fungi reveals gene family expansions associated with fungal pathogenesis丝状真菌的比较基因组分析揭示了基因家族扩张与真菌发病机制有关.pdfVIP

Comparative Genome Analysis of Filamentous Fungi Reveals Gene Family Expansions Associated with Fungal Pathogenesis 1 2 2 1 2 Darren M. Soanes , Intikhab Alam , Mike Cornell , Han Min Wong , Cornelia Hedeler , Norman W. 2 2 3 4 1 Paton , Magnus Rattray , Simon J. Hubbard , Stephen G. Oliver , Nicholas J. Talbot * 1 School of Biosciences, Geoffrey Pope Building, University of Exeter, Exeter, United Kingdom, 2 School of Computer Science, University of Manchester, Manchester, United Kingdom, 3 Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester, United Kingdom, 4 Department of Biochemistry, University of Cambridge, Sanger Building, Cambridge, United Kingdom Abstract Fungi and oomycetes are the causal agents of many of the most serious diseases of plants. Here we report a detailed comparative analysis of the genome sequences of thirty-six species of fungi and oomycetes, including seven plant pathogenic species, that aims to explore the common genetic features associated with plant disease-causing species. The predicted translational products of each genome have been clustered into groups of potential orthologues using Markov Chain Clustering and the data integrated into the e-Fungi object-oriented data warehouse (.uk/). Analysis of the species distribution of members of these clusters has identified proteins that are specific to filamentous fungal species and a group of proteins found only in plant pathogens. By comparing the gene inventories of filamentous, ascomycetous phytopathogenic and free-living speci