comparative genomic analysis of clinical strains of campylobacter jejuni from south africa比较基因组分析临床株空肠弯曲杆菌的南非.pdfVIP

Comparative Genomic Analysis of Clinical Strains of Campylobacter jejuni from South Africa ˜ 1 2 1 1 3 Beatriz Quinones *, Magalie R. Guilhabert , William G. Miller , Robert E. Mandrell , Albert J. Lastovica , Craig T. Parker1* 1 United States Department of Agriculture-Agricultural Research Service, Produce Safety and Microbiology Research Unit, Albany, California, United States of America, 2 AgraQuest, Inc., Davis, California, United States of America, 3 Department of Biotechnology, University of the Western Cape, Bellville, South Africa Abstract Background: Campylobacter jejuni is a common cause of acute gastroenteritis and is also associated with the post-infectious ´ neuropathies, Guillain-Barre and Miller Fisher syndromes. In the Cape Town area of South Africa, C. jejuni strains with Penner ´ heat-stable (HS) serotype HS:41 have been observed to be overrepresented among cases of Guillain-Barre syndrome. The present study examined the genetic content of a collection of 32 South African C. jejuni strains with different serotypes, ´ including 13 HS:41 strains, that were recovered from patients with enteritis, Guillain-Barre or Miller Fisher syndromes. The sequence-based typing methods, multilocus sequence typing and DNA microarrays, were employed to potentially identify distinguishing features within the genomes of these C. jejuni strains with various disease outcomes. Methodology/Principal Findings: Comparative genomic analyses de