α-synuclein and dj-1 as potential biological fluid biomarkers for parkinson’s diseaseα-synuclein和dj-1作为潜在生物流体帕金森疾病的生物标记物.pdfVIP

Int. J. Mol. Sci. 2010, 11, 4257-4266; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review -Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease Masaaki Waragai *, Kazunari Sekiyama, Akio Sekigawa, Yoshiki Takamatsu, Masayo Fujita and Makoto Hashimoto Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo, 183-8526, Japan; E-Mails: sekiyama-kz@igakuken.or.jp (K.S.); sekigawa-ak@igakuken.or.jp (A.S.); takamatsu-ys@igakuken.or.jp (Y.T.); fujita-ms@igakuken.or.jp (M.F.); hashimoto-mk@igakuken.or.jp (M.H.) * Author to whom correspondence should be addressed; E-Mail: waragai@kk.iij4u.or.jp; Fax: +81-42-321-8678. Received: 14 September 2010; in revised form: 20 October 2010 / Accepted: 28 October 2010 / Published: 29 October 2010 Abstract: Parkinson’s disease (PD) is the most common form of movement disorder and affects approximately 4% of the population aged over 80 years old. Currently, PD cannot be prevented or cured, and no single diagnostic biomarkers are available. Notably, recent studies suggest that two familial PD-linked molecules, -synuclein and DJ-1, are present in cerebrospinal fluid (CSF) and that their levels may be altered during the progression of PD. In this regard, sensitive and accurate methods for evaluation of -synuclein and DJ-1 levels in the CSF and blood have been developed, and the results suggest that the levels of both