whole-genome analysis of human influenza a virus reveals multiple persistent lineages and reassortment among recent h3n2 viruses人类流感病毒全基因组分析揭示了多个持久化血统和重组最近h3n2病毒.pdfVIP

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whole-genome analysis of human influenza a virus reveals multiple persistent lineages and reassortment among recent h3n2 viruses人类流感病毒全基因组分析揭示了多个持久化血统和重组最近h3n2病毒.pdf

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whole-genome analysis of human influenza a virus reveals multiple persistent lineages and reassortment among recent h3n2 viruses人类流感病毒全基因组分析揭示了多个持久化血统和重组最近h3n2病毒

Open access, freely available online PLoS BIOLOGY Whole-Genome Analysis of Human Influenza A Virus Reveals Multiple Persistent Lineages and Reassortment among Recent H3N2 Viruses 1 2 2 3 4 3 1 Edward C. Holmes , Elodie Ghedin , Naomi Miller , Jill Taylor , Yiming Bao , Kirsten St. George , Bryan T. Grenfell , 2 2 4* 5 Steven L. Salzberg , Claire M. Fraser , David J. Lipman , Jeffery K. Taubenberger 1 Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America, 2 Institute for Genomic Research, Rockville, Maryland, United States of America, 3 Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, 4 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America, 5 Department of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, Maryland, United States of America Understanding the evolution of influenza A viruses in humans is important for surveillance and vaccine strain selection. We performed a phylogenetic analysis of 156 complete genomes of human H3N2 influenza A viruses collected between 1999 and 2004 from New York State, United States, and observed multiple co-circulating clades with different population frequencies. Strikingly, phylogenies inferred for individual gene segments revealed that multiple reassortment events had occurred amon