structure of an mmyb-like regulator from c. aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes英文论文.pdfVIP

Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes 1,2 3 1,2 1,4,5 1,6 Qingping Xu , Gilles P. van Wezel , Hsiu-Ju Chiu , Lukasz Jaroszewski , Heath E. Klock , 1,6 1,2 1,6,7 1,4,5 ´ 1,7 Mark W. Knuth , Mitchell D. Miller , Scott A. Lesley , Adam Godzik , Marc-Andre Elsliger , Ashley M. Deacon1,2, Ian A. Wilson1,7* 1Joint Center for Structural Genomics, La Jolla, California, United States of America, 2 Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, United States of America, 3 Gorlaeus Laboratories, Department of Biology, Leiden University, Leiden, The Netherlands, 4 Center for Research in Biological Systems, University of California San Diego, La Jolla, California, United States of America, 5 Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America, 6 Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America, 7 Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America Abstract Actinomycetes are important bacterial sources of antibiotics and other secondary metabolites. Many antibiotic gene clusters are controlled by pathway-specific activators that act in response to growth conditions. Here we present the crystal structure of an MmyB-like transcriptio