spontaneous autoimmunity in 129 and c57bl6 mice—implications for autoimmunity described in gene-targeted mice自发的自身免疫和129年c57bl6 mice-implications中描述为自身免疫基因的老鼠.pdfVIP

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spontaneous autoimmunity in 129 and c57bl6 mice—implications for autoimmunity described in gene-targeted mice自发的自身免疫和129年c57bl6 mice-implications中描述为自身免疫基因的老鼠.pdf

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spontaneous autoimmunity in 129 and c57bl6 mice—implications for autoimmunity described in gene-targeted mice自发的自身免疫和129年c57bl6 mice-implications中描述为自身免疫基因的老鼠

Open access, freely available online PLoS BIOLOGY Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice 1 1 1 1 1 2 Anne E. Bygrave , Kirsten L. Rose , Josefina Cortes-Hernandez , Joanna Warren , Robert J. Rigby , H. Terence Cook , 1¤ 1 1* Mark J. Walport , Timothy J. Vyse , Marina Botto 1 Rheumatology Section, Eric Bywaters Centre, Imperial College, London, United Kingdom, 2 Department of Histopathology, Faculty of Medicine, Imperial College, London, United Kingdom Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of gene-targeted mice have been reported to develop SLE, implicating the null genes in the causation of disease. However, hybrid strains between 129 and C57BL/6 mice, widely used in the generation of gene-targeted mice, develop spontaneous autoimmunity. Furthermore, the genetic background markedly influences the autoimmune phenotype of SLE in gene-targeted mice. This suggests an important role in the expression of autoimmunity of as-yet-uncharacterised background genes originating from these parental mouse strains. Using genome-wide linkage analysis, we identified several susceptibility loci, derived from 129 and C57BL/6 mice, mapped in the lupus-prone hybrid (129 3 C57BL/6) model. By creating a C57BL/6 congenic strain carrying a 129-derived Chromosome 1 segment, we found that this 129 interval was sufficient to mediate the loss of tolerance to nuclear antigens, which had prev