structural characterization of calcium alginate matrices by means of mechanical and release tests藻酸钙矩阵的结构特征的机械和发布测试.pdfVIP

Molecules 2009, 14, 3003-3017; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Structural Characterization of Calcium Alginate Matrices by Means of Mechanical and Release Tests Mario Grassi 1,*, Chiara Sandolo 2, Danilo Perin 1,3, Tommasina Coviello 2, Romano Lapasin 1 4 and Gabriele Grassi 1 Dipartimento di Ingegneria Chimica, dellAmbiente e delle Materie prime, Università di Trieste, P.le Europa 1, 34127 Trieste, Italy; E-mail: romanol@dicamp.univ.trieste.it (R.L.) 2 Dipartimento di Chimica e Tecnologie del Farmaco, Università di Roma “La Sapienza”, P.le Aldo Moro 5, 00185 Roma, Italy; E-mails: chiara.sandolo@uniroma1.it (C.S.), tommasina.coviello@uniroma1.it (T.C.) 3 PROTOS Research Institute, Via Flavia 23/1, 34100 Trieste, Italy; E-mail: perin@ (D.P.) 4 Dipartimento di Scienze della vita, Università di Trieste, Via L. Giorgieri 1, I-34127 Trieste, Italy; E-mail: ggrassi@units.it (G.G.) * Author to whom correspondence should be addressed; E-mail: mariog@dicamp.univ.trieste.it Received: 25 June 2009; in revised form: 4 August 2009 / Accepted: 10 August 2009 / Published: 12 August 2009 Abstract: In this paper we have concentrated on the characterization of calcium alginate hydrogels loaded with a model drug (myoglobin) by means of a mechanical approach; in addition, release tests of myoglobin from alginate hydrogels were performed. At a fixed temperature, relaxation tests (mechanical study) were carried out on matrices constituted by differe