六味地黄软胶囊对初诊2型糖尿病患者胰岛素敏感性及胰岛β细胞功.docVIP

六味地黄软胶囊对初诊2型糖尿病患者胰岛素敏感性及胰岛β细胞功 　【摘要】 目的 探讨六味地黄软胶囊对2型糖尿病患者胰岛素敏感性及胰岛β细胞功能的 影响 。 方法 将214例初诊2型糖尿病患者按体质量指数(BMI)和临床症状分为非肥胖型组103例和肥胖型组111例，2组均又分为六味地黄软胶囊合二甲双胍亚组和二甲双胍亚组。各组在常规饮食、运动指导下予相应药物 治疗 。采用稳态模型评估胰岛素敏感性，观察各组胰岛素抵抗指数（IR）、胰岛素分泌指数（IS）、胰岛素原（FPI）与免疫活性胰岛素（IRI）比例。结果 肥胖型组2个亚组治疗后FPI/IRI与治疗前比较差异均有统计学意义(Plt;0.05)；非肥胖型组六味地黄软胶囊合二甲双胍亚组治疗后IR、IS、FPI/IRI与治疗前比较差异有统计学意义(Plt;0.05，Plt;0.01)，二甲双胍亚组治疗后IS、FPI/IRI与治疗前比较差异有统计学意义(Plt;0.05)；但非肥胖型组IR(%)、IS(%)改善均较肥胖型组明显，2组比较差异有统计学意义(Plt;0.05)。结论 六味地黄胶囊较适合于2型糖尿病非肥胖型的治疗。 【关键词】 胶囊；糖尿病，2型；胰岛素；胰岛素原；胰岛素抗药性；中西医结合疗法 　　 The effect of LiuwEidihuang capsule on insulin sensitive,β-cell function of patients with type 2 diabetes mellitus 　　【Abstract】 Objective To observe the effect of LiuwEIdihuang capsule on insulin sensitive, islet β-cell function of patients with type 2 diabetes mellitus at first diagnosis. Methods 111 patients with type 2 diabetes mellitus at first diagnosis were divided into two groups according to BMI and clinical symptoms, non-fat group (n=103) and fat group (n=111),then the two groups were divided into two subgroups, Liuweidihuang capsule with metformin subgroup and metformin subgroup. The patients in different groups, on the basis of routine diet and exercise, were treated with corresponding drugs. The fasting plasma glucose (FPG),fasting plasma proninsulin（FPI）, immunoreactive insulin（IRI）, insulin resistance index (IR), insulin secretion index（IS）and FPI/IRI in all the groups were detected and analyzed. Results There was a significant difference in FPI/IRI of two subgroups of fat group before and after treatment (Plt;0.05)；there were significant differences in IR,IS,FPI/IRI of Liuweidihuang capsule with metformin subgroup of non-fat group before and after treatment (Plt;0.05 or Plt;0.01); there were significant differences in IS, FPI/IRI of metformin subgroup before and after treatment (Plt;0.05)；there was a significant difference in IR and ISbettwen fat group and non-fat group(Plt;0.05). Conclusion Liuweidihuang capsule is eff