antigen-engaged b cells undergo chemotaxis toward the t zone and form motile conjugates with helper t cellsantigen-engaged b细胞发生趋化作用向t区,形成能动的轭合物与辅助t细胞.pdfVIP

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antigen-engaged b cells undergo chemotaxis toward the t zone and form motile conjugates with helper t cellsantigen-engaged b细胞发生趋化作用向t区,形成能动的轭合物与辅助t细胞.pdf

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antigen-engaged b cells undergo chemotaxis toward the t zone and form motile conjugates with helper t cellsantigen-engaged b细胞发生趋化作用向t区,形成能动的轭合物与辅助t细胞

Open access, freely available online PLoS BIOLOGY Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells 1[ 2[¤a 3 4 5¤b Takaharu Okada , Mark J. Miller , Ian Parker , Matthew F. Krummel , Margaret Neighbors , 5¤c 5¤d 2* 1* Suzanne B. Hartley , Anne O’Garra , Michael D. Cahalan , Jason G. Cyster 1 Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America, 2 Department of Physiology and Biophysics, University of California, Irvine, California, United States of America, 3 Department of Neurobiology and Behavior, University of California, Irvine, California, United States of America, 4 Department of Pathology, University of California, San Francisco, California, United States of America, 5 Department of Immunobiology, DNAX Research Institute, Palo Alto, California, United States of America Interactions between B and T cells are essential for most antibody responses, but the dynamics of these interactions are poorly understood. By two-photon microscopy of intact lymph nodes, we show that upon exposure to antigen, B cells migrate with directional preference toward the B-zone–T-zone boundary in a CCR7-dependent manner, through a region that exhibits a CCR7-ligand gradient. Initially the B cells show reduced motility, but after 1 d, motility is increased to approximately 9 lm/min. Antigen-engaged B cells pair with antigen-specific helper T cells for 10 to more than 60 min, whereas non-antigen-spec