有哪些信誉好的足球投注网站anti-müllerian hormone serum values and ovarian reserve can it predict a decrease in fertility after ovarian stimulation by art cycles她们血液中的抗苗勒氏管激素血清值和卵巢储备能预测减少生育后艺术卵巢刺激周期.pdfVIP
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anti-müllerian hormone serum values and ovarian reserve can it predict a decrease in fertility after ovarian stimulation by art cycles她们血液中的抗苗勒氏管激素血清值和卵巢储备能预测减少生育后艺术卵巢刺激周期
¨
Anti-Mullerian Hormone Serum Values and Ovarian
Reserve: Can It Predict a Decrease in Fertility after
Ovarian Stimulation by ART Cycles?
Tito Silvio Patrelli*, Salvatore Gizzo, Nicoletta Sianesi, Luca Levati, Antonio Pezzuto, Bruno Ferrari,
Alberto Bacchi Modena
Department of Gynecology, Obstetrics and Neonatology, University of Parma, Parma, Italy
Abstract
Background: A variety of indicators of potentially successful ovarian stimulation cycles are available, including biomarkers
such as anti-Mullerian hormone. The aim of our study was to confirm the usefulness of serum anti-Mullerian hormone assay
in predicting ovarian response and reproductive outcome in women eligible for ART cycles.
Materials: Forty-six women undergoing ART cycles at the Centre for Reproductive Medicine in Parma were recruited from
March-to-June 2010. Inclusion criteria: age,42 years; body-mass-index = 20–25; regular menstrual cycles; basal serum FSH
concentration ,12 IU/L and basal serum estradiol concentration ,70 pg/mL. The couples included in our study reported a
variety of primary infertility causes. All women underwent FSH stimulation and pituitary suppression (GnRH-agonist/GnRH-
antagonist protocols). Women were considered poor-responders if thay had #3 oocytes; normal-responders 4–9 oocytes
and high-responders $10 oocytes. Serum samples for the AMH assays were obtained on the first and last days of
stimulation. A P value #0.05 was considered statistically significant.
Result: FSH levels increased significantly when AMH levels decreased. The total dose of r-FSH administered to induce
ovulation was not correlated to AMH. The number of follicles on the hCG, serum estradiol levels on the hCG-day, and the
number of retrieved oocytes were significantly correlated to AMH. The number of fertilized oocytes was sign
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