anti-hiv activity in cervical-vaginal secretions from hiv-positive and -negative women correlate with innate antimicrobial levels and igg antibodies抗艾滋病活动cervical-vaginal分泌物hiv阳性和消极的女性与天生的抗菌和免疫球蛋白抗体水平.pdfVIP

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2017-09-07 发布于上海
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anti-hiv activity in cervical-vaginal secretions from hiv-positive and -negative women correlate with innate antimicrobial levels and igg antibodies抗艾滋病活动cervical-vaginal分泌物hiv阳性和消极的女性与天生的抗菌和免疫球蛋白抗体水平.pdf

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anti-hiv activity in cervical-vaginal secretions from hiv-positive and -negative women correlate with innate antimicrobial levels and igg antibodies抗艾滋病活动cervical-vaginal分泌物hiv阳性和消极的女性与天生的抗菌和免疫球蛋白抗体水平

Anti-HIV Activity in Cervical-Vaginal Secretions from HIV- Positive and -Negative Women Correlate with Innate Antimicrobial Levels and IgG Antibodies 1. 1. 1 2 3 4 Mimi Ghosh , John V. Fahey , Zheng Shen , Timothy Lahey , Susan Cu-Uvin , Zhijin Wu , Kenneth 3 5 6,7,8 6 1 Mayer , Peter F. Wright , John C. Kappes , Christina Ochsenbauer , Charles R. Wira * 1 Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, 2 Department of Microbiology and Immunology and Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, 3 The Immunology Center, The Miriam Hospital, Brown University, Providence, Rhode Island, United States of America, 4 Department of Community Health and Center for Statistical Sciences, Brown University, Providence, Rhode Island, United States of America, 5 Department of Pediatrics, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, 6 Department of Medicine, University of Alabama, Birmingham, Alabama, United States of America, 7 Department of Microbiology, University of Alabama, Birmingham, Alabama, United States of America, 8 Department of Pathology, University of Alabama, Birmingham, Alabama, United States of America Abstract Background: We investigated the impact of antimicrobials in cervicovaginal lavage (CVL) from HIV(+) and HIV( 2) women on target cell infection with HIV. Since female reproductive tract (FRT) secretions contain a spectrum of antimicrobials, we hypothesized that CVL from healthy HIV(+) and ( 2) women inhibit HIV infection.