antigen-specific b memory cell responses to plasmodium falciparum malaria antigens and schistosoma haematobium antigens in co-infected malian children恶性疟原虫疟疾抗原记忆b细胞反应的埃及血吸虫抗原和抗原在感染马里的孩子.pdfVIP

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antigen-specific b memory cell responses to plasmodium falciparum malaria antigens and schistosoma haematobium antigens in co-infected malian children恶性疟原虫疟疾抗原记忆b细胞反应的埃及血吸虫抗原和抗原在感染马里的孩子.pdf

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antigen-specific b memory cell responses to plasmodium falciparum malaria antigens and schistosoma haematobium antigens in co-infected malian children恶性疟原虫疟疾抗原记忆b细胞反应的埃及血吸虫抗原和抗原在感染马里的孩子

Antigen-Specific B Memory Cell Responses to Plasmodium falciparum Malaria Antigens and Schistosoma haematobium Antigens in Co-Infected Malian Children 1 1 2 2,3 2 2 Kirsten E. Lyke *, Amy Wang , Abdoulaye Dabo , Charles Arama , Modibo Daou , Issa Diarra , 1,4 2 1 Christopher V. Plowe , Ogobara K. Doumbo , Marcelo B. Sztein 1 Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 2 Malaria Research and Training Center, University of Bamako, Bamako, Mali, 3 Department of Immunology, University of Stockholm, Stockholm, Sweden, 4 Howard Hughes Medical Institute, Baltimore, Maryland, United States of America Abstract Polyparasitism is common in the developing world. We have previously demonstrated that schistosomiasis-positive (SP) Malian children have age-dependent protection from malaria compared to matched schistosomiasis-negative (SN) children. Evidence of durable immunologic memory to malaria antigens is conflicting, particularly in young children and the effect of concomitant schistomiasis upon acquisition of memory is unknown. We examined antigen-specific B memory cell (MBC) frequencies (expressed as percentage of total number of IgG-secreting cells) in 84 Malian children aged 4–14 to malaria blood-stage antigens, apical membrane antigen 1 (AMA-1) and merozoite surface protein 1 (MSP-1) and to schistosomal antigens, Soluble Worm Antigenic Preparation (SWAP) and Schistosoma Egg Antigen (SEA), at a time point during the malaria