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antigen-displaying lipid-enveloped plga nanoparticles as delivery agents for a plasmodium vivax malaria vaccineantigen-displaying lipid-enveloped plga纳米粒作为间日疟原虫疟疾疫苗交付代理
Antigen-Displaying Lipid-Enveloped PLGA Nanoparticles
as Delivery Agents for a Plasmodium vivax Malaria
Vaccine
1,2 1,2,6 3 3 3
James J. Moon , Heikyung Suh , Mark E. Polhemus , Christian F. Ockenhouse , Anjali Yadava ,
Darrell J. Irvine1,2,4,5,6*
1 Department of Materials Science and Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America, 2 Department of
Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America, 3 Division of Malaria Vaccine Development,
Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, 4 Koch Institute for Integrative Cancer Research, Massachusetts Institute of
Technology (MIT), Cambridge, Massachusetts, United States of America, 5 Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, United States of America,
6 Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
Abstract
The parasite Plasmodium vivax is the most frequent cause of malaria outside of sub-Saharan Africa, but efforts to develop
viable vaccines against P. vivax so far have been inadequate. We recently developed pathogen-mimicking polymeric vaccine
nanoparticles composed of the FDA-approved biodegradable polymer poly(lactide-co-glycolide) acid (PLGA) ‘‘enveloped’’
by a lipid membrane. In this study, we sought to determine whether this vaccine delivery platform could be applied to
enhance the immune response against P. vivax sporozoites. A candidate malaria antigen, VMP001, was conjugated to the
lipid membrane of the particles, and an immunostimulatory molecule, monophosphoryl lipid A (MPLA), was incorporated
into the lipid membranes, creating pathogen-mimicking na
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