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androgens contribute to sex differences in myocardial remodeling under pressure overload by a mechanism involving tgf-β雄激素导致性别差异在心肌重构机制涉及tgf-β压力过载
Androgens Contribute to Sex Differences in Myocardial
Remodeling under Pressure Overload by a Mechanism
Involving TGF-b
1,5 1,5 1,5 ´ 2,5 3,5 4,5
Cecilia Montalvo , Ana V. Villar , David Merino , Raquel Garcıa , Miguel Ares , Miguel Llano ,
4,5 ´ ´ 1,5 2,5
Manuel Cobo , Marıa A. Hurle *, J. Francisco Nistal
´ ´ ´
1 Departamento de Fisiologıa y Farmacologıa, Facultad de Medicina, Universidad de Cantabria, Santander, Spain, 2 Servicio de Cirugıa Cardiovascular, Hospital
´ ´ ´
Universitario Marques de Valdecilla, Santander, Spain, 3 Hospital Comarcal de Laredo, Cantabria, Spain, 4 Servicio de Cardiologıa, Hospital Universitario Marques de
´ ´ ´
Valdecilla, Santander, Spain, 5 Instituto de Formacion e Investigacion Marques de Valdecilla (IFIMAV), Santander, Spain
Abstract
Background: In clinical studies, myocardial remodeling in aortic valve stenosis appears to be more favorable in women than
in men, even after menopause. In the present study, we assessed whether circulating androgens contribute to a less
favorable myocardial remodeling under pressure overload in males. We examined sex-related differences in one-year-old
male and female mice. Whereas male mice at this
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