androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer雄激素调节的精氨酸酶1的表达,精氨酸酶2和interleukin-8人类前列腺癌.pdfVIP

Androgen-Regulated Expression of Arginase 1, Arginase 2 and Interleukin-8 in Human Prostate Cancer 1 1 2 1 1 Philippe O. Gannon , Jessica Godin-Ethier , Matthew Hassler , Nathalie Delvoye , Meghan Aversa , 1 ´ 1 1 1,3 ´ 1,4 . Alexis O. Poisson , Benjamin Peant , Mona Alam Fahmy , Fred Saad *, Rejean Lapointe * , Anne-Marie Mes-Masson1,4. ´ ´ ´ 1 Centre de recherche du Centre hospitalier de l’Universite de Montreal (CRCHUM) and Institut du cancer de Montreal, Montreal, Quebec, Canada, 2 Department of ´ ´ Chemistry, McGill University, Montreal, Quebec, Canada, 3 Department of Surgery, CHUM, Universite de Montreal, Montreal, Quebec, Canada, 4 Department of Medicine, ´ ´ Universite de Montreal, Montreal, Quebec, Canada Abstract Background: Prostate cancer (PCa) is the most frequently diagnosed cancer in North American men. Androgen-deprivation therapy (ADT) accentuates the infiltration of immune cells within the prostate. However, the immunosuppressive pathways regulated by androgens in PCa are not well characterized. Arginase 2 (ARG2) expression by PCa cells leads to a reduced activation of tumor-specific T cells. Our hypothesis was that androgens could regulate the expression of ARG2 by PCa cells. Methodology/Principal Findings: In this report, we demonstrate that both ARG1 and ARG2