anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated aktikkβnf-κb signaling麻醉剂异丙酚减少内毒素的炎症通过抑制活性氧种类aktikkβnf-κb信号.pdfVIP

Anesthetic Propofol Reduces Endotoxic Inflammation by Inhibiting Reactive Oxygen Species-regulated Akt/IKKb/ NF-kB Signaling 1,2 1,3 3 3,4 3 Chung-Hsi Hsing *, Ming-Chung Lin , Pui-Ching Choi , Wei-Ching Huang , Jui-In Kai , Cheng-Chieh 3,4,5 3,6 3 3,4 7 7 Tsai , Yi-Lin Cheng , Chia-Yuan Hsieh , Chi-Yun Wang , Yu-Ping Chang , Yu-Hong Chen , Chia- Ling Chen7, Chiou-Feng Lin3,4,7* 1 Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan, 2 Department of Anesthesiology, College of Medicine, Taipei Medical University, Taipei, Taiwan, 3 Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 4 Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 5 Department of Nursing, Chung Hwa University of Medical Technology, Tainan, Taiwan, 6 Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 7 Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan Abstract Background: Anesthetic propofol has immunomodulatory effects, particularly in the area of anti-inflammation. Bacterial endotoxin lipopolysaccharide (LPS) induces inflammation through toll-like receptor (TLR) 4 signaling. We investigated the molecular actions of propofol against LPS/TLR4-induced inflammatory activation in murine RAW264.7 macrophages. Methodology/Principal Findings: Non-cytotoxic levels of propofol reduced LPS-induced inducible nitric oxide synthase