有哪些信誉好的足球投注网站analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity在卵巢癌上皮和间叶细胞标记的分析,将揭示表型异质性和可塑性.pdfVIP
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analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity在卵巢癌上皮和间叶细胞标记的分析,将揭示表型异质性和可塑性
Analysis of Epithelial and Mesenchymal Markers in
Ovarian Cancer Reveals Phenotypic Heterogeneity and
Plasticity
1,6 1 1 1 1 2 ¨ 3
Robert Strauss , Zong-Yi Li , Ying Liu , Ines Beyer , Jonas Persson , Pavel Sova , Thomas Moller , Sari
4 4 6,7 5 5 6,7 ´
Pesonen , Akseli Hemminki , Petra Hamerlik , Charles Drescher , Nicole Urban , Jiri Bartek , Andre
Lieber1,2*
1 Division of Medical Genetics, University of Washington, Seattle, Washington, United States of America, 2 Department of Pathology, University of Washington, Seattle,
Washington, United States of America, 3 Department of Neurology, University of Washington, Seattle, Washington, United States of America, 4 Cancer Gene Therapy
Group, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland, 5 Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of
America, 6 Danish Cancer Society, Department of Cell Cycle and Cancer, Center for Genotoxic Stress Research, Copenhagen, Denmark, 7 Laboratory of Genomic Integrity
and Institute of Molecular and Translational Medicine, Palacky University, Olomouc, Czech Republic
Abstract
In our studies of ovarian cancer cells we have identified subpopulations of cells that are in a transitory E/M hybrid stage, i.e.
cells that simultaneously express epithelial and mesenchymal markers. E/M cells are not homogenous but, in vitro and in
vivo, contain subsets that can be distinguished based on a number of phenotypic features, including the subcellular
localization of E-cadherin, and the expression levels of Tie2, CD133, and C
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